Unveiling structural and energetic characterization of the emissive RNA alphabet anchored in the methylthieno[3,4-d]pyrimidine heterocycle core
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Unveiling structural and energetic characterization of the emissive RNA alphabet anchored in the methylthieno[3,4-d]pyrimidine heterocycle core
- June 14, 2026
- Posted by: Stem Skills Lab
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Physical Chemistry Chemical Physics · 2024 · Cited 7 times
Mohit Chawla, Albert Poater, Romina Oliva, Luigi Cavallo
This theoretical study characterises a set of fluorescent, non-natural RNA bases (mthA, mthG, mthC, mthU) built on a methylthieno-pyrimidine core. It examines their structures and energetics to understand how they behave as light-emitting analogues of the natural bases. Such ’emissive’ nucleotides are useful laboratory tools for tracking RNA structure and activity.
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