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Guides and tutorials

Computational life sciences, explained step by step.

Real commands, real parameters, and the errors that actually catch people out. Written by researchers who use these tools.

A docking search box rendered as a golden wireframe around a ligand, with a teal DNA helix behind
Career Guide How to Find a Bioinformatics Internship: BSc and MSc Four real routes into a bioinformatics internship, what each one asks of you, and how to write the email most students never… Ragini Mishra 15 min read Molecular Modeling MODELLER Tutorial: Build a Homology Model Step by Step Install MODELLER, pick a template, write the align2d alignment, run AutoModel and rank your models by DOPE score, using the official tutorial… Dr. Abdul Rajjak Shaikh 16 min read Bioinformatics ProtParam for a Vaccine Construct: Reading Every Number Run ProtParam on your multi-epitope construct and learn what each number means, which cutoff is real, and what to change when a… Ragini Mishra 16 min read Molecular Modeling How to Calculate Protein-Protein Binding Affinity Score your docked protein-protein complex with PRODIGY and HawkDock MM/GBSA, read dG and Kd correctly, and learn why a docking score is… Dr. Abdul Rajjak Shaikh 12 min read Molecular Modeling How to Remove Water Molecules From a PDB File for Docking Strip HOH waters and crystallisation additives from a PDB file with PyMOL, ChimeraX or pdb-tools, and learn which structural waters to keep. Dr. Abdul Rajjak Shaikh 14 min read Career Guide Free Bioinformatics Certifications Worth Doing as a Student Compare free bioinformatics certifications, see which credentials cost nothing, which charge for the certificate, and which issue none at all. Ragini Mishra 13 min read Molecular Modeling How to Dock a Ligand to a GPCR or Membrane Protein with AutoDock Vina (Step by Step) Dock a ligand into a GPCR with AutoDock Vina: pick the right activation state, strip BRIL and T4 lysozyme, and place the… Dr. Abdul Rajjak Shaikh 14 min read Career Guide Life Science PhD, Fellowship and Scholarship Deadlines: 31 Close by 21 September 2026 Thirty-one funding deadlines close by 21 September 2026, two of them today. Twenty new entries were verified this week, including ten European… Dr. Abdul Rajjak Shaikh 40 min read Molecular Modeling AutoDock Vina Errors and How to Fix Them: The 10 That Stop Beginners Decode the 10 AutoDock Vina errors that stop beginners, from PDBQT parsing failures to grid box mistakes, with the exact command that… Dr. Abdul Rajjak Shaikh 14 min read

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