Immunoinformatics-driven design of a multi-epitope vaccine targeting neonatal rotavirus with focus on outer capsid proteins VP4 and VP7 and non structural proteins NSP2 and NSP5
Immunoinformatics-driven design of a multi-epitope vaccine targeting neonatal rotavirus with focus on outer capsid proteins VP4 and VP7 and non structural proteins NSP2 and NSP5
- June 14, 2026
- Posted by: Stem Skills Lab
Scientific Reports · 2025 · Cited 17 times
Arijit Das Sharma, Jorge Samuel Leon Magdaleno, Himanshu Singh, Andrés Felipe Cuspoca Orduz, Luigi Cavallo, Mohit Chawla
Rotavirus is still a leading cause of severe diarrhoea in young children, and existing live vaccines are only 40–60% effective. Using immunoinformatics, this study designs a multi-epitope vaccine targeting the rotavirus capsid proteins VP4 and VP7 plus the non-structural proteins NSP2 and NSP5. The candidate combines ten predicted epitopes shown to be antigenic, non-allergenic and non-toxic, and molecular- and immune-simulation tests predicted stable receptor binding and a strong immune response — to be confirmed in laboratory studies.
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