Immunoinformatics-Aided Design and In Vivo Validation of a Peptide-Based Multiepitope Vaccine Targeting Canine Circovirus
Immunoinformatics-Aided Design and In Vivo Validation of a Peptide-Based Multiepitope Vaccine Targeting Canine Circovirus
- June 14, 2026
- Posted by: Stem Skills Lab
ACS Pharmacology & Translational Science · 2022 · Cited 48 times
Vikas Kaushik, Pankaj Jain, Nahid Akhtar, Amit Joshi, Lovi Raj Gupta, Ravneet Kaur Grewal, Romina Oliva, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla
This study designs a peptide-based multi-epitope vaccine against canine circovirus using immunoinformatics, then goes a step beyond most such work by validating it in vivo. Predicted antigenic epitopes were assembled into a vaccine construct and tested for their ability to raise an immune response in an animal model. Pairing computational design with experimental validation strengthens the case for the candidate.
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