ACS Pharmacology & Translational Science 2022
Immunoinformatics-Aided Design and In Vivo Validation of a Peptide-Based Multiepitope Vaccine Targeting Canine Circovirus
Vikas Kaushik, Pankaj Jain, Nahid Akhtar, Amit Joshi, Lovi Raj Gupta, Ravneet Kaur Grewal, Romina Oliva, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla
This study designs a peptide-based multi-epitope vaccine against canine circovirus using immunoinformatics, then goes a step beyond most such work by validating it in vivo. Predicted antigenic epitopes were assembled into a vaccine construct and tested for their ability to raise an immune response in an animal model. Pairing computational design with experimental validation strengthens the case for the candidate.
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Cite this paper
Vikas Kaushik, Pankaj Jain, Nahid Akhtar, Amit Joshi, Lovi Raj Gupta, Ravneet Kaur Grewal, Romina Oliva, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla (2022) Immunoinformatics-Aided Design and In Vivo Validation of a Peptide-Based Multiepitope Vaccine Targeting Canine Circovirus. ACS Pharmacology & Translational Science. https://doi.org/10.1021/acsptsci.2c00130
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