Immunoinformatics Aided Design and In-Vivo Validation of a Cross-Reactive Peptide Based Multi-Epitope Vaccine Targeting Multiple Serotypes of Dengue Virus
Immunoinformatics Aided Design and In-Vivo Validation of a Cross-Reactive Peptide Based Multi-Epitope Vaccine Targeting Multiple Serotypes of Dengue Virus
- June 14, 2026
- Posted by: Stem Skills Lab
Frontiers in Immunology · 2022 · Cited 51 times
Vikas Kaushik, Sunil Krishnan G, Lovi Raj Gupta, Utkarsh Kalra, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla
Dengue affects over 400 million people a year, and current vaccines remain limited. This study uses immunoinformatics to design a multi-epitope vaccine covering all four dengue serotypes, selecting ten conserved, interferon-inducing epitopes. Molecular docking and molecular dynamics predicted stable binding to the TLR5 receptor, and — unusually — one epitope was synthesised and shown to raise antibodies in a rabbit model, supporting the design’s immunogenicity.
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