COCOMAPS 2.0: a web server for identifying, analyzing, and visualizing atomic interactions in protein–protein and protein–nucleic acid complexes - StemSkills Lab
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Bioinformatics 2025

COCOMAPS 2.0: a web server for identifying, analyzing, and visualizing atomic interactions in protein–protein and protein–nucleic acid complexes

Mohit Chawla, Utkarsh Kalra, Andrea Petta, Suraj Sharma, Abdul Rajjak Shaikh, Luigi Cavallo, Romina Oliva

COCOMAPS 2.0 is a free web server for studying how proteins bind to other proteins or to nucleic acids. It maps and visualizes the contact interface between two molecules, which residues touch and how much surface they bury, automating an analysis structural biologists otherwise do by hand. This release adds more comprehensive and accurate interface comparison on top of the original tool’s residue-level and buried-surface-area analysis. For students working on docking or protein complexes, it is a practical way to read and compare binding interfaces without writing custom code.

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Mohit Chawla, Utkarsh Kalra, Andrea Petta, Suraj Sharma, Abdul Rajjak Shaikh, Luigi Cavallo, Romina Oliva (2025) COCOMAPS 2.0: a web server for identifying, analyzing, and visualizing atomic interactions in protein–protein and protein–nucleic acid complexes. Bioinformatics. https://doi.org/10.1093/bioinformatics/btaf606

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