ACS Applied Materials & Interfaces 2024
Detecting Hachimoji DNA: An Eight-Building-Block Genetic System with MoS2 and Janus MoSSe Monolayers
Vasudeo Babar, Sitansh Sharma, Abdul Rajjak Shaikh, Romina Oliva, Mohit Chawla, Luigi Cavallo
Building toward affordable DNA sequencing, this study uses density functional theory to test MoS₂ and Janus MoSSe monolayers as sensors for the eight-letter Hachimoji DNA system. It maps how each base sits on the material, how charge transfers, and how the current–voltage signal changes after adsorption, finding good sensing performance and high sensitivity for certain bases. The results help guide the design of 2D-material platforms for sequencing.
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Cite this paper
Vasudeo Babar, Sitansh Sharma, Abdul Rajjak Shaikh, Romina Oliva, Mohit Chawla, Luigi Cavallo (2024) Detecting Hachimoji DNA: An Eight-Building-Block Genetic System with MoS2 and Janus MoSSe Monolayers. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.3c18400
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