Development of a vaccine construct against Pneumocystis jirovecii pneumonia using computational tools
Development of a vaccine construct against Pneumocystis jirovecii pneumonia using computational tools
- June 14, 2026
- Posted by: Stem Skills Lab
NAR Genomics and Bioinformatics · 2025 · Cited 2 times
Ragini Mishra, Nahid Akhtar, Jorge Samuel Leon Magdeleno, Abdul Rajjak Shaikh, Manik Prabhu Narsing Rao, Neeta Raj Sharma, Luigi Cavallo, Mohit Chawla
This study uses an immunoinformatics (computer-guided) approach to design a candidate vaccine against Pneumocystis jirovecii, a fungus that causes serious pneumonia in people with weakened immune systems. The team screened the pathogen’s major surface glycoprotein for antigenic epitopes, filtered them for safety and immune-activating potential, and assembled ten into a vaccine construct with adjuvants. Molecular docking, molecular dynamics, and immune-simulation tests suggested the design binds Toll-like receptors stably and could provoke a useful immune response — a starting point for laboratory validation.
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