Viruses 2022
Immunoinformatics-Aided Design of a Peptide Based Multiepitope Vaccine Targeting Glycoproteins and Membrane Proteins against Monkeypox Virus
Nahid Akhtar, Vikas Kaushik, Ravneet Kaur Grewal, Atif Khurshid Wani, Chonticha Suwattanasophon, Kiattawee Choowongkomon, Romina Oliva, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla
Prompted by the multi-country monkeypox outbreak, this study uses immunoinformatics to design a peptide-based multi-epitope vaccine against the virus, targeting its glycoproteins and membrane proteins. Seven epitopes predicted to be antigenic, non-allergenic, non-toxic and interferon-activating were linked with adjuvants into a candidate. Molecular docking, molecular dynamics and immune simulations predicted stable binding to the human TLR5 receptor and a useful immune response, pending laboratory validation.
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Nahid Akhtar, Vikas Kaushik, Ravneet Kaur Grewal, Atif Khurshid Wani, Chonticha Suwattanasophon, Kiattawee Choowongkomon, Romina Oliva, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla (2022) Immunoinformatics-Aided Design of a Peptide Based Multiepitope Vaccine Targeting Glycoproteins and Membrane Proteins against Monkeypox Virus. Viruses. https://doi.org/10.3390/v14112374
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