Secreted Aspartyl Proteinases Targeted Multi-Epitope Vaccine Design for Candida dubliniensis Using Immunoinformatics
Secreted Aspartyl Proteinases Targeted Multi-Epitope Vaccine Design for Candida dubliniensis Using Immunoinformatics
- June 14, 2026
- Posted by: Stem Skills Lab
Vaccines · 2023 · Cited 42 times
Nahid Akhtar, Jorge Samuel Leon Magdaleno, Suryakant Ranjan, Atif Khurshid Wani, Ravneet Kaur Grewal, Romina Oliva, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla
This study designs a multi-epitope vaccine against Candida dubliniensis, a fungus that causes oral and invasive infections in immunocompromised patients and is developing drug resistance. Using immunoinformatics, the team targeted the fungus’s secreted aspartyl proteinase proteins, predicting eight safe, immune-activating epitopes and linking them with adjuvants. Docking, molecular dynamics and immune-simulation results pointed to stable TLR5 binding and a strong predicted immune response, supporting future laboratory testing.
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