Immunoinformatics-aided rational design of a multi-epitope vaccine targeting feline infectious peritonitis virus
Immunoinformatics-aided rational design of a multi-epitope vaccine targeting feline infectious peritonitis virus
- June 14, 2026
- Posted by: Stem Skills Lab
Frontiers in Veterinary Science · 2023 · Cited 28 times
Mohit Chawla, Andrés Felipe Cuspoca, Nahid Akthar, Jorge Samuel Leon Magdaleno, Siriluk Rattanabunyong, Chonticha Suwattanasophon, Nathjanan Jongkon, Kiattawee Choowongkomon, Abdul Rajjak Shaikh, Tabarak Malik, Luigi Cavallo
This study designs a multi-epitope vaccine against feline infectious peritonitis, an often-fatal disease caused by a feline coronavirus, using immunoinformatics. The team analysed the virus’s spike protein, predicted eleven T-cell epitopes screened for antigenicity, toxicity and allergenicity, and assembled them with adjuvants. Molecular docking and molecular dynamics indicated stable binding to the feline TLR4 receptor, pointing toward experimental validation.
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