Frontiers in Veterinary Science 2023
Immunoinformatics-aided rational design of a multi-epitope vaccine targeting feline infectious peritonitis virus
Mohit Chawla, Andrés Felipe Cuspoca, Nahid Akthar, Jorge Samuel Leon Magdaleno, Siriluk Rattanabunyong, Chonticha Suwattanasophon, Nathjanan Jongkon, Kiattawee Choowongkomon, Abdul Rajjak Shaikh, Tabarak Malik, Luigi Cavallo
This study designs a multi-epitope vaccine against feline infectious peritonitis, an often-fatal disease caused by a feline coronavirus, using immunoinformatics. The team analysed the virus’s spike protein, predicted eleven T-cell epitopes screened for antigenicity, toxicity and allergenicity, and assembled them with adjuvants. Molecular docking and molecular dynamics indicated stable binding to the feline TLR4 receptor, pointing toward experimental validation.
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Cite this paper
Mohit Chawla, Andrés Felipe Cuspoca, Nahid Akthar, Jorge Samuel Leon Magdaleno, Siriluk Rattanabunyong, Chonticha Suwattanasophon, Nathjanan Jongkon, Kiattawee Choowongkomon, Abdul Rajjak Shaikh, Tabarak Malik, Luigi Cavallo (2023) Immunoinformatics-aided rational design of a multi-epitope vaccine targeting feline infectious peritonitis virus. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2023.1280273
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