Journal of Biomolecular Structure and Dynamics 2024
T cell epitope based vaccine design while targeting outer capsid proteins of rotavirus strains infecting neonates: an immunoinformatics approach
Arijit Das Sharma, Ravneet Kaur Grewal, Suresh Gorle, Andrés Felipe Cuspoca, Vikas Kaushik, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla
This study designs a multi-epitope vaccine against the rotavirus strains that infect newborns, using an immunoinformatics approach focused on the outer capsid proteins VP4 and VP7. Ten T-cell epitopes predicted to be antigenic, non-allergenic, non-toxic and stable were assembled with adjuvants into a vaccine construct. Molecular dynamics and immune-simulation studies indicated stable binding to the TLR5 receptor and a promising immune response, motivating future laboratory validation.
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Arijit Das Sharma, Ravneet Kaur Grewal, Suresh Gorle, Andrés Felipe Cuspoca, Vikas Kaushik, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla (2024) T cell epitope based vaccine design while targeting outer capsid proteins of rotavirus strains infecting neonates: an immunoinformatics approach. Journal of Biomolecular Structure and Dynamics. https://doi.org/10.1080/07391102.2023.2226721
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