T cell epitope based vaccine design while targeting outer capsid proteins of rotavirus strains infecting neonates: an immunoinformatics approach
T cell epitope based vaccine design while targeting outer capsid proteins of rotavirus strains infecting neonates: an immunoinformatics approach
- June 14, 2026
- Posted by: Stem Skills Lab
Journal of Biomolecular Structure and Dynamics · 2024 · Cited 5 times
Arijit Das Sharma, Ravneet Kaur Grewal, Suresh Gorle, Andrés Felipe Cuspoca, Vikas Kaushik, Abdul Rajjak Shaikh, Luigi Cavallo, Mohit Chawla
This study designs a multi-epitope vaccine against the rotavirus strains that infect newborns, using an immunoinformatics approach focused on the outer capsid proteins VP4 and VP7. Ten T-cell epitopes predicted to be antigenic, non-allergenic, non-toxic and stable were assembled with adjuvants into a vaccine construct. Molecular dynamics and immune-simulation studies indicated stable binding to the TLR5 receptor and a promising immune response, motivating future laboratory validation.
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